Adenovirus inhibition of cellular protein synthesis is prevented by the drug 2-aminopurine.

JT Huang, RJ Schneider - Proceedings of the National …, 1990 - National Acad Sciences
protein synthesis, but the mechanism has not been established. In this report we …
cellular protein synthesis by adenovirus is prevented in cells by treatment with the drug 2-aminopurine. …

Protein synthesis in pseudorabies virus-infected cells: decreased expression of protein kinase PKR, and effects of 2-aminopurine and adenine

ML Wong, YR Yen - Virus research, 1998 - Elsevier
cells, we found that the inhibition of host protein synthesis by PRV was partially prevented by
these two drugs, … obtained from adenovirus-infected cells suggested that partial reversion of …

2-aminopurine enhances the oncolytic activity of an E1b-deleted adenovirus in hepatocellular carcinoma cells

D Sharon, M Schümann, S MacLeod, R McPherson… - Plos one, 2013 - journals.plos.org
… can inhibit both viral and cellular protein synthesis through … RNA-deleted adenovirus in certain
cells, the drug may also be … in E1b-deleted virus production in HepG2 cells treated with 2′…

Adenovirus inhibition of cellular protein synthesis involves inactivation of cap-binding protein

J Huang, RJ Schneider - Cell, 1991 - cell.com
… reduce the level of most cell mRNAs at a time when their translation is inhibited (Babich et
al., 1983). In addition, the drug 2-aminopurine (2AP) prevents host translation shutoff by Ad …

Studies on the inhibition of cellular protein synthesis by adenovirus

J Huang - 1991 - search.proquest.com
… translation after Ad infection can be prevented by the kinase inhibitor 2-aminopurine (2AP). …
seen in wt300 virus-infected cells was largely prevented by this drug (Fig. 3, compare lane 4 …

Adenovirus inhibition of cell translation facilitates release of virus particles and enhances degradation of the cytokeratin network

Y Zhang, RJ Schneider - Journal of virology, 1994 - Am Soc Microbiol
… We found that if adenovirus is prevented from inhibiting cell … late Ad inhibition of cellular
protein synthesis, which is to prevent … is prevented by the drug 2-aminopurine. Proc. Natl. …

[HTML][HTML] The molecular basis of viral oncolysis: usurpation of the Ras signaling pathway by reovirus

JE Strong, MC Coffey, D Tang, P Sabinin… - The EMBO …, 1998 - embopress.org
… of reovirus protein synthesis in untransformed cells. The … To test this idea, we used the
drug 2-aminopurine which has … of adenovirus, a viral gene product VAI RNA is synthesized in …

Adenovirus inhibition of cellular protein synthesis and the specific translation of late viral mRNAs

Y Zhang, RJ Schneider - Seminars in Virology, 1993 - Elsevier
… The late phase of adenovirus (Ad) infection is marked by the inhibition of cellular protein
synthesis, the … Finally, the drug 2-aminopurine (2-AP) was shown to prevent Ad shut-off of …

Functional Expression and RNA Binding Analysis of the Interferon-Induced, Double-Stranded RNA-Activated, 68,000-Mr Protein Kinase in a Cell-Free System

MG Katze, M Wambach, ML Wong… - … and cellular biology, 1991 - Taylor & Francis
… for the native p68 provided that the kinase inhibitor, 2-aminopurine, was present during
the in … Adenovirus inhibition of cellular protein synthesis is prevented by the drug 2-aminopurine. …

Inhibition of translation in cells infected with a poliovirus 2Apro mutant correlates with phosphorylation of the alpha subunit of eucaryotic initiation factor 2

RE O'Neill, VR Racaniello - Journal of virology, 1989 - Am Soc Microbiol
inhibited by 2-aminopurine, we propose that 2-aminopurine … 2A-2-infected, 2-aminopurinetreated
cells at 5 h postinfection (… of host protein synthesis in adenovirusinfected cells. Virology …